HA Cross Linked Gels
High Viscosity Gel Particulation
Cosmeceuticals
HA Cross Liked Gels
Krieger has developed expertise in the processing of Cross Linked Hyaluronic Acid based viscous injectable gels under contained and sterile conditions.
We have designed a fully new processing plant for manufacturing high molecular weight cross linked hyaluronic acid based gels. (classified as injectable fillers)
The Krieger HA manufacturing plant integrates cross linking vessel, gel sizing, purifying and final particle reduction of the finished gel in one seamless to use processing unit.
A fast and secure way to manufacture cosmeceutical injectable gels with controlled particle size without losing molecular weight.
For R&D labs we provide various small scale equipment for your cosmeceuticals process, ranging from HA Dissolving tanks, cross linking systems, gel cutting devices, purifying systems and sieves or Homogenisers for particulation of your finalised cross linked gel.
At our new Hyaluronic Acid Process Development Center we welcome customers to learn and test innovative Cosmeceutical manufacturing methods.
Contact us to see how Krieger can be of assistance in your strategy to enter the fascinating field of Cosmeceuticals.
HA Cross Linked Skid
Our fully integrated skid provides automated manufacturing of Cross linked gels.
Our Skid includes a cross linking vessel, a caking and cutting tray and a purifying vessel.
Caking & Cutting Tray
Krieger’s new developed caking and cutting tray fulfills many process steps:
- Direct entry from Cross linking vessel
- Heat control during the caking process
- Cutting of the cake/ viscous gel into blocks/humps
- Transfer of the cutted gel direct into the purifying vessel
- Variable batch sizes can be chosen between the min/max volume of the tray
Our cutting /caking tray is designed for SIP/CIP in place and is fully integrated in the CIP/SIP cycles of the entire cross linking skid.
Purifying vessel
Designed for changing frequently the wash liquid Purifies the the cross linked gels and removes toxity from the cross linking agent.
The washed gel can be discharged directly by a special bottom valve designed for full discharge to particulation vessels of the Krieger gel particulation system.
Gel Particulation Press Systems
The Krieger High Viscosity gel particulation system press the washed gel through sieves. The sieves mesh sizes and number of sieves are defined in function of the required final particle size.
The system uses an intelligent Hydraulic system to monitor/regulate the high pressures during the Sieving Process to ensure Sieves are not damaged during the process.
For your specific processing requirements, we can adapt volumes
and equipments as per your needs with our QbD engineering.
Scale Down equipment for R&D
For Lab & R&D we have our HA lab Mi Molto and Lab presses
That allow to Simulate the Krieger HA cross linking gel manufacturing process.
HA Tabletop Lab Press
HA Mi Molto
